Detailed view for TVAG_379940

Basic information

TDR Targets ID: 884190
Trichomonas vaginalis, Clan MH, family M20, peptidase T-like metallopeptidase
Source Database / ID: 

pI: 5.0241 | Length (AA): 426 | MW (Da): 47397 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01546   Peptidase family M20/M25/M40
PF07687   Peptidase dimerisation domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0008270   zinc ion binding  
GO:0008237   metallopeptidase activity  
GO:0045148   tripeptide aminopeptidase activity  
GO:0016787   hydrolase activity  
GO:0008152   metabolic process  
GO:0006518   peptide metabolic process  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134039)

Species Accession Gene Product
Escherichia coli b1127   peptidase T
Entamoeba histolytica EHI_158320   peptidase T, putative
Leishmania braziliensis LbrM.17.0180   peptidase t, putative,peptidase T, putative, metallo-peptidase, ClanMH, family M20B
Leishmania donovani LdBPK_170250.1   peptidase t, putative
Leishmania infantum LinJ.17.0250   peptidase t, putative,peptidase T, putative, metallo-peptidase, ClanMH, family M20B
Leishmania major LmjF.17.0140   peptidase t, putative,peptidase T, putative, metallo-peptidase, ClanMH, family M20B
Leishmania mexicana LmxM.17.0140   peptidase t, putative,peptidase T, putative, metallo-peptidase, ClanMH, family M20B
Schistosoma mansoni Smp_111420   peptidase T (M20 family)
Trypanosoma brucei gambiense Tbg972.7.7240   peptidase t, putative
Trypanosoma brucei Tb927.7.6270   peptidase t, putative
Trypanosoma congolense TcIL3000_7_5130   peptidase t, putative
Trypanosoma cruzi TcCLB.506513.110   peptidase t, putative
Trichomonas vaginalis TVAG_379940   Clan MH, family M20, peptidase T-like metallopeptidase

Essentiality

TVAG_379940 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.6270 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.6270 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.6270 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.6270 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b1127 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0003 1 1
0.0003 1 1
0.001 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_379940 (Trichomonas vaginalis), Clan MH, family M20, peptidase T-like metallopeptidase
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